Biochemical Properties of the Toxins of Clostridium novyi and Clostridium hemolyticum.

نویسندگان

  • R C Bard
  • L S McClung
چکیده

The report of Oakley, Warrack, and Clarke (1947) on the toxins of the Clostridium novyi (oedematiens) group and of Clostridium hemolyticum indicates the complexity of this topic and presents the pertinent historical data. It is known that the toxins C. novyi and C. hemolyticum involve a lecithinase catalyzing the hydrolysis of lecithin to phosphorylcholine and a diglyceride. In view of the existence of such toxic enzymes as the lecithinases, it was considered possible that the hemotoxins produced by these species might be related to lysolecithin. This phospholipid is a strongly hemolytic substance produced from lecithin by lecithinase A activity and destroyed by lecithinase B hydrolysis to yield nonhemolytic end products. We have demonstrated the ability of lecithinase B to reduce the hemolytic potency of the toxins of C. novyi, type B, and C. hemolyticum, and this is taken as evidence for the presence of lysolecithin in these toxins.

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عنوان ژورنال:
  • Journal of bacteriology

دوره 56 5  شماره 

صفحات  -

تاریخ انتشار 1948